Jiang X,
Jiang H,
Yang Q,
Cheng Y,
Lu L.-Q,
*,
Tunge JA,
Xiao W.-J.
*
Central China Normal University, Wuhan, Lanzhou Institute of Chemical Physics (LICP),
Henan Normal University, Xinxiang, and Lanzhou University, P. R. of China
Photoassisted Cobalt-Catalyzed Asymmetric Reductive Grignard-Type Addition of Aryl
Iodides.
J. Am. Chem. Soc. 2022;
144: 8347-8354
DOI:
10.1021/jacs.2c02481
Key words
cobalt catalysis - photoredox catalysis - Hantzsch esters - asymmetric reaction -
Grignard-type addition
Significance
A photoredox cobalt-catalyzed enantioselective approach to a Grignard-type addition
of aryl iodides to aldehydes is reported. Notably, the mild reaction conditions enable
a wide range of functional groups and heterocycles to be tolerated.
Comment
4CzIPN is used as the photocatalyst, which can be excited under visible-light irradiation.
The use of Hantzsch ester as the reductant is notable because it avoids the generation
of stoichiometric metal waste.
