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Planta Med 2017; 83(01/02): 111-116
DOI: 10.1055/s-0042-107252
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Diterpenoid Alkaloids from Delphinium ajacis and Their Anti-RSV Activities

Li Yang
1   Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
,
Yu-Bo Zhang
1   Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
,
Ling Zhuang
1   Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
,
Tao Li
2   School of Biomedical Sciences, The University of Hong Kong, Central and Western District, Hong Kong
,
Neng-Hua Chen
1   Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
,
Zhong-Nan Wu
1   Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
,
Pan Li
1   Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
,
Yao-Lan Li
1   Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
,
Guo-Cai Wang
1   Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
› Author Affiliations
Further Information

Publication History

received 30 November 2015
revised 06 April 2016

accepted 15 April 2016

Publication Date:
12 July 2016 (online)

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Abstract

Five new diterpenoid alkaloids, ajacisines A–E (1–5), were isolated from Delphinium ajacis, along with seven known alkaloids (6–12). On the basis of their spectral data (IR, UV, HR-ESI-MS, 1D and 2D NMR) and chemical properties, the structures of compounds 1–12 were identified. All isolated compounds were evaluated for their in vitro antiviral activities against respiratory syncytial virus, and compounds 3–5 and 8 exhibited moderate to weak effects with IC50 values of 75.2 ± 1.1, 35.1 ± 0.6, 10.1 ± 0.3, and 50.2 ± 0.5 µM, respectively.

Key words

Delphinium ajacis - Ranunculaceae - diterpenoid alkaloid - anti-RSV activity

Supporting Information

 

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