Macrocyclization and Scaffold Hopping Improves Selectivity and ADME Properties of HPK1 Inhibitors

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Synfacts 2023; 19(04): 0415
DOI: 10.1055/s-0042-1752649

Innovative Drug Discovery and Development

Contributor(s):

Antonia F. Stepan (Roche)

,

Ferdinand H. Lutter (Janssen Pharmaceutica)

,

Ulrich Lücking (FoRx Therapeutics)

macrocycles - kinase inhibition - selectivity - ADME - scaffold hopping

Article published online:
17 March 2023

Georg Thieme Verlag KG
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