Transfusion Requirements with Hybrid Management of Placenta Accreta Spectrum Incorporating Targeted Embolization and a Selective Use of Delayed Hysterectomy

Abstract

Objective This study compares the number of units of red blood cells (RBCs) transfused in patients with placenta accreta spectrum (PAS) treated with or without a multidisciplinary algorithm that includes placental uterine arterial embolization (P-UAE) and selective use of either immediate or delayed hysterectomy.

Study Design This is a retrospective study of deliveries conducted at a tertiary care hospital from 2001 to 2018 with pathology-confirmed PAS. Those with previable pregnancies or microinvasive histology were excluded. To improve the equity of comparison, analyses were made separately among scheduled and unscheduled cases, therefore patients were assigned to one of four cohorts as follows: (1) scheduled/per-algorithm, (2) scheduled/off-algorithm, (3) unscheduled/per-algorithm, or (4) unscheduled/off-algorithm. Primary outcomes included RBCs transfused and estimated blood loss (EBL). Secondary outcomes included perioperative complications and disposition.

Results Overall, 95 patients were identified, with 87 patients meeting inclusion criteria: 36 treated per-algorithm (30 scheduled and 6 unscheduled) and 51 off-algorithm patients (24 scheduled and 27 unscheduled). Among scheduled deliveries, 9 (30.0%) patients treated per-algorithm received RBCs compared with 20 (83.3%) patients treated off-algorithm (p < 0.01), with a median (interquartile range [IQR]) of 3.0 (2.0, 4.0) and 6.0 (2.5, 7.5) units transfused (p = 0.13), respectively. Among unscheduled deliveries, 5 (83.3%) per-algorithm patients were transfused RBCs compared with 25 (92.6%) off-algorithm patients (p = 0.47) with a median (IQR) of 4.0 (2.0, 6.0) and 8.0 (3.0, 10.0) units transfused (p = 0.47), respectively. Perioperative complications were similar between cohorts.

Conclusion A multidisciplinary algorithm including P-UAE and selective use of delayed hysterectomy is associated with a lower rate of blood transfusion in scheduled but not unscheduled cases.

Key Points

• An algorithm with delayed hysterectomy had less transfusion in scheduled, but not unscheduled, cases.

• Over time, more cases were managed per algorithm; among scheduled cases, the transfusion rate and volume transfused decreased.

• There were similar transfusion outcomes among off-algorithm cases, regardless if delivery was scheduled.

Keywords

postpartum hemorrhage - massive transfusion protocol - placental accreta spectrum - morbidly adherent placenta - multidisciplinary teams - uterine artery embolization - accreta centers for excellence

Details of Ethics Approval

This study has been approved on June 25, 2018 by the Duke Institutional Review Board (identifiers: Pro00100007 and Pro00025434) and has been determined to be in compliance with all Health Insurance Portability and Accountability Act regulations.

Note

Data from this manuscript were presented as an oral presentation at Society for Gynecologic Oncology (SGO) Annual Meeting, Scientific Plenary V: Operations Matter, on March 19, 2019, in Honolulu, HI.

Publication History

Received: 24 March 2021

Accepted: 03 June 2022

Article published online:
16 August 2022

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