PDF icon PDF herunterladen
J Pediatr Infect Dis 2023; 18(02): 107-112
DOI: 10.1055/s-0042-1758055
Case Report

A Case of Adult-Onset Kawasaki Disease in an Adolescent Occurring during the COVID-19 Pandemic

Christoph Aebi
1   Division of Pediatric Infectious Disease, Department of Pediatrics, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland
,
Nina Schöbi
1   Division of Pediatric Infectious Disease, Department of Pediatrics, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland
,
Andrea Duppenthaler
1   Division of Pediatric Infectious Disease, Department of Pediatrics, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland
,
Matthias V. Kopp
1   Division of Pediatric Infectious Disease, Department of Pediatrics, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland
3   Center North (ARCN), Member of the German Lung Research Center (DZL), University of Lübeck, Lübeck, Germany
,
Martin Glöckler
2   Division of Pediatric Cardiology, Department of Cardiology, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland
,
Philipp K. A. Agyeman
1   Division of Pediatric Infectious Disease, Department of Pediatrics, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland
› Institutsangaben
› Weitere Informationen
Auch verfügbar aufeRef
  Lizenzen und Reprints
Preview

Abstract

We report the occurrence of the adult-onset type of Kawasaki disease (KD) with classic mucocutaneous manifestations of KD, cholestatic liver disease, multiple splenic infarcts, and residual multiple coronary artery dilatations in a previously healthy 14-year-old male adolescent 16 days after having received one dose of the BNT162b2 coronavirus disease 2019 (COVID-19) mRNA vaccine. First, the report serves to highlight the diagnostic challenges of adult-onset KD often resulting in therapeutic delay and the frequently reported occurrence of persistent cardiovascular sequelae. Second, the report emphasizes that the temporal association of KD with the administration of a COVID-19 vaccine will likely be a frequent constellation in the near future, raising questions of a causative association. While there is currently no evidence of such an association in persons above 5 years of age, large-scale vaccination of children below 5 years of age will require close surveillance of vaccine-related adverse events.

Keywords

adult-onset - Kawasaki disease - vaccine - SARS-CoV-2 - COVID-19

Ethics Statement

Bern University Hospital General Consent (GC) was granted by the patient and his parents for the use of routine clinical data in the medical record for research purposes. In addition, oral informed consent was obtained from the patient and his parents as required by the University Hospital for case reports. The Cantonal Ethics Committee, Bern, Switzerland, declared nonresponsibility.


Author Contributions

C. A., N. S., A. D., M. V. K., M. G., and P. K. A. A. cared for the patient. C. A., A. D., and P. K. A. A. drafted the manuscript. M. G. performed and evaluated the cardiac imaging studies. All authors contributed to the final version of the manuscript.




Publikationsverlauf

Eingereicht: 01. Juli 2022

Angenommen: 15. September 2022

Artikel online veröffentlicht:
23. November 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany