Can cannabidiol improve the symptoms associated with periodontitis?

Periodontitis is a chronic inflammatory disease that affects the gum and bone tissues supporting teeth, and there are currently a few effective treatment options. If left untreated, periodontitis can lead to tooth loss and other systemic diseases. Cannabidiol (CBD) is a non-psychoactive component of Cannabis sp. with anti- inflammatory and analgesic properties. In recent years, there has been a growing interest in the potential use of CBD for treating periodontitis, and different preclinical studies have evaluated several mechanisms of action. This study aims to provide an overview of the current state of knowledge about the effects of CBD on periodontitis, the mechanisms of action, therapeutic potential, and side effects. CBD may reduce inflammation and pain associated with the disease, and further promote the regeneration of bone and connective tissue by modulating the synthesis of pro-inflammatory cytokines. Additionally, CBD might have antibacterial properties to control the bacterial infection that causes periodontitis. Despite promising health effects, clinical evidence of CBD effects in periodontitis is still missing. Overall, CBD appears to have significant potential as a treatment for periodontitis, but further research is needed to fully understand its effects and ensure its safety and efficacy.

Funding This work was supported by the George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș Research Grant number 163/7/10.01.2023.

 

MissingLinkText

Publication History

Article published online:
16 November 2023