Phytochemical and pharmacological characteristics of an extract from Eryngium planum L. herb

Medicinal plants are valuable sources of biologically active substances, which may show a positive therapeutic effect in various pathological processes. Eryngium species have been used in Ukrainian folk medicine for a long time. E. planum L. is mostly widespread in Ukraine.

The aim of the research was to study the phytochemical composition and pharmacological activity of an E. planum herb thick extract.

The extract was obtained with 70% ethanol by fractional maceration (3 times). The combined extracts were evaporated to a thick extract, which is the dark viscous mass with a specific smell. The yield of the extract was 22.1±0.8%. In the extract, tannins (8.1±0.23%), flavonoids (6.1±0.13%) and total polyphenols (21.8±0.97%) were established. Caffeic acid and rutin were identified by TLC.

Hepatoprotective activity of the extract was studied in the tetrachloromethane method in a rat model. The extract significantly reduces toxic effect in the case of acute toxic damage to the liver. Providing hepatoprotective activity is at the level of the reference drug – Silibor from Silybum marianum. The extract also has anti-inflammatory effect in the formalin edema model. At 1, 3, 5 h of the experiment the extract showed anti-exudative activity of 16.85%, 19.80%, 21.05%, respectively, which is close to the reference drug – diclofenac sodium.

The possibility of implementation of E. planum herb and its extract as a medicinal plant material has been proven by conducting phytochemical and pharmacological research.

Funding This work was supported by the MSCA4Ukraine (1232466).

 

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Conflict of Interest

The authors declare no conflict of interest.

Publikationsverlauf

Artikel online veröffentlicht:
16. November 2023