Planta Med 2023; 89(14): 1325
DOI: 10.1055/s-0043-1773963
Abstracts
Monday 3rd July 2023 | Poster Session I
Phytochemistry I – General

Unravelling the ecotype influence on metabolomics and toxicity of Corema album L.

Eliana Fernandes
1   1 Centre of Marine Sciences (CCMAR), Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal
,
Riccardo Trentin Trentin
2   Department of Biology, University of Padova, Via U. Bassi 58/B, 35131 Padova, Italy
,
Maria João Rodrigues
1   1 Centre of Marine Sciences (CCMAR), Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal
,
Luís Custódio
1   1 Centre of Marine Sciences (CCMAR), Campus de Gambelas, University of Algarve, 8005-139 Faro, Portugal
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Previous work showed relevant radical scavenging activities of ethanol and acetone extracts of Corema album [1]. This work expended upon that work by evaluating the ecotype influence on metabolomics and toxicity of methanol leaf extracts of Corema album. Leaves were collected from adult plants from populations located in two distinct areas: east (CAE) and west (CAW) coast of Southern Portugal. Extracts were evaluated for metabolomics by LC-ESI-HRMS/MS and toxicity towards murine RAW 264.7 macrophages, murine bone marrow stromal [S17], human embryonic kidney [HEK 293] and human hepatocellular carcinoma [HepG2] cells. Untargeted metabolomics revealed significant differences in the composition of the extracts; however pinocembrin was the major compound in both. Both extracts were toxic against tested cells. Our results suggest that C. album contains bioactive polyphenolic compounds with antioxidant and cytotoxic properties that could be further explored in the pharmaceutical area.

Funding This work received Portuguese national funds from FCT – Foundation for Science and Technology through projects UIDB/04326/2020, UIDP/04326/2020, and LA/P/0101/2020, the PhD grant (UI/BD/151301/2121: EF), FCT program contract (UIDP/04326/2020: MJR) and FCT Scientific Employment Stimulus (CEECIND/00425/2017: LC).


 

Conflict of Interest

The authors declare no conflict of interest.

  • References

  • 1 Fernandes E., Correia H., Rodrigues M.J., Castañeda-Loaiza V., Pereira C., Custódio L.. Exploring the biotechnological value of Corema album leaves. Planta Medica 2022; 88 (15) P-216
    PubMedSearch in Google Scholar

Publication History

Article published online:
16 November 2023

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  • References

  • 1 Fernandes E., Correia H., Rodrigues M.J., Castañeda-Loaiza V., Pereira C., Custódio L.. Exploring the biotechnological value of Corema album leaves. Planta Medica 2022; 88 (15) P-216
    PubMedSearch in Google Scholar