Anti-osteoclastogenic activity of compounds from Nelumbo nucifera Gaertn.

To obtain antiosteoclastogenic active compounds from the natural sources, 18 compounds were isolated from the leaves and stems of Nelumbo nucifera Gaertner (Nymphaeaceae). All the isolated compounds were examined for their antiosteoclastogenic activity. Preliminary results of the TRAP staining on RAW [1] [2]

264.7 cells indicated that compounds 1 and 11 possess potential inhibitory effects on RANKL-induced osteoclast formation. Further bioassay investigation was carried out to reveal that compounds 1 and 11 suppressed RANKL-induced osteoclast formation in a concentration-dependent manner with inhibition up to 55% and 78% at concentrations of 10 μM, respectively. The findings provided valuable insights for the discovery and structural modification of aporphine alkaloids as antiosteoclastogenic lead compounds ([Fig. 1]).

Fig. 1  Chemical structures of compounds 1-18 from N. nucifera.

 

MissingLinkText

• References

• 1 Vu NK, Ha MT, Ha YJ, Kim CS., Gal M, Ngo QMT., Kim JA, Lee JH, Min BS.. Structures and antiosteoclastogenic activity of compounds from edible lotus (Nelumbo nucifera Gaertn.) leaves and stems. Fitoterapia 2022; 162: 105294
• 2 Tran PT, Ngo TQM, Lee S, Kim O, Tran HNK, Hwangbo C, Min BS, Lee JH.. Identification of anti- osteoclastogenic compounds from Cleistocalyx operculatus flower buds and their effects on RANKL-induced osteoclastogenesis. J. Funct. Foods. 2019; 60: 103388

Publikationsverlauf

Artikel online veröffentlicht:
16. November 2023