Planta Med 2023; 89(14): 1342
DOI: 10.1055/s-0043-1774007
Abstracts
Monday 3rd July 2023 | Poster Session I
Phytopharmacology I – General; respiratory; cardiac

Chemical Constituents from an Oyster-derived Fungus Westerdykella dispersa Ca4-13

Shu-Jung Huang
1   Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei, Taiwan
,
Li-Kwan Chang
2   Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan
,
Yi-Shan Lu
2   Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan
,
George Hsiao
3   Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
4   Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
,
Tzong-Huei Lee
1   Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei, Taiwan
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    Chromatographic separation of the liquid-state fermented products of the fungal strain Westerdykella dispersa Ca4-13 isolated from an edible oyster Crassostrea angulata collected from Yunlin, Taiwan has resulted in the isolation of compounds 1 – 6. The structures of compounds 1 – 6 were characterised by spectroscopic analysis to be westeroic acid A, westeroic acid B, auranticin A, auranticin B, pilobolusone C, and epi-radicinol ([Fig. 1]), respectively. Westeroic acid A, a rare C28 polyketide with a 6/6-spiro-linked δ- lactone moiety, and westeroic acid B, a C14 polyketide with a γ-lactone functionality, were previously unreported chemical entities. Of the compounds identified, 1, 2 and 6 exhibited anti-inflammatory activities with IC50 values ranging from 9.5 to 14.7 μM without any cytotoxicity, and compound 4 exhibited anti- Epstein-Barr virus (EBV) activity with an EC50 value of 38.1 μM. The aldehyde group of auanticin B (4) would play a vital role in its anti-EBV activity comparing the activity of 4 with those of its two analogues, auranticin A (3) and pilobolusone C (5).

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    Fig. 1 Chemical structures of compounds 1-6 identified in this study.

     

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    Artikel online veröffentlicht:
    16. November 2023

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    Fig. 1 Chemical structures of compounds 1-6 identified in this study.