New triterpene saponins of the aerial parts of Sanicula europaea

Sanicula europaea L. has been used in European traditional medicine for centuries and revealed up to now the presence of six triterpene saponins. Further representatives of this compound class were described incompletely after hydrolysis experiments. Therefore, the aim of this study was the investigation of the saponin fraction of the aerial plant parts of this species. Among the isolated components, the structure elucidation of four compounds was possible. Two compounds were identified as the known saponins Bonarienosid A and Bonarienosid B, known from Hydrocotyle bonariensis (Araliaceae), but are described here for the first time as constituents of S. europaea. The other two isolates were identified as 3-O- [glucopyranosyl-(1→2)]-arabinopyranosyl-(1→3)-glucuronopyranosyl-21-O-acetyl-22-O-senecioyl-R1- barrigenol as well as 3-O-glucopyranosyl-(1→2)-glucuronopyranosyl-21-O-acetyl-22-O-senecioyl-R1- barrigenol. Both compounds represent new natural products due to the presence of a senecioic acid unit in contrast to their more common angelic acid analogues Saniculasaponin II, isolated from Sanicula elata var. chinensis and 3-O-glucopyranosyl-(1→2)-glucuronopyranosyl-21-O-acetyl-22-O-angeloyl-R1-barrigenol isolated from the roots of Eryngium planum.

 

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Artikel online veröffentlicht:
16. November 2023