Planta Med 2023; 89(14): 1356
DOI: 10.1055/s-0043-1774054
Abstracts
Tuesday 4th July 2023 | Poster Session II
Phytochemistry II - Antimicrobials; Cosmetics; Essential oils; Nutraceuticals; Biotechnology

Chemical Composition and Cytotoxicity of Litsea rubicunda Essential Oil from Malaysia

WanMohdNuzul Wan Salleh
1   Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Malaysia
,
Abubakar Siddiq Salihu
2   Department of Pure and Industrial Chemistry, Faculty of Natural and Applied Sciences, Umaru Musa Yar’adua University, Nigeria
,
Nur Abdul Kadir
1   Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Malaysia
,
Nurunajah Ab Ghani
3   Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Malaysia
4   Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Malaysia
,
Nurulfazlina Edayah Rasol
3   Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Malaysia
4   Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Malaysia
,
Shamsul Khamis
5   Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Malaysia
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    This work aimed to investigate, for the first time, the chemical composition and cytotoxicity of Litsea rubicunda Kosterm. essential oil. The essential oil was obtained through hydrodistillation, and its volatile components were analysed through gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS) techniques. Twenty-eight components, constituting 90.2% of the oil content, were identified. The most prominent components were β-caryophyllene (29.5%), caryophyllene oxide (11.2%), α- humulene (8.5%) and germacrene D (8.0%). The cytotoxicity of the essential oil was evaluated using an MTT assay. The essential oil exhibited weak cytotoxicity against three cancer cell lines which are HepG2, MCF7 and A549 with the IC50 values ranging from 59.5 – 62.4 μg/mL. The present study highlights the potential of using a plant essential oil as an alternative for the development of chemopreventive or cosmetic agents for the pharmaceutical industry.


     

    Publication History

    Article published online:
    16 November 2023

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