Anti-inflammatory activity of medicinal plants from the traditional medicine of Atacama People (Calama, Chile)

With principal aims to better understand and search for new anti-inflammatory compounds, we investigated the antioxidant, anti-inflammatory and wound-healing proprieties of several medicinal plants from the Atacama People’s traditional medicine. To begin, cytotoxic (cell viability) and anti-inflammatory (production of pro-inflammatory cytokines) activities were assessed of extracts obtained from classical maceration procedures from selected medicinal plants species. The less polar extracts from Fabiana sp. (F. squamata and F. denudata, Solanaceae) showed the more promising in vitro results, inhibiting the production of pro-inflammatory cytokines (82% and 89% for F. squamata and 61% and 77% for F. denudata of IL-1β and IL-10 inhibition respectively at 50 µg/mL, final concentration) by LPS-stimulated peripheral blood mononuclear cells (PBMC) with no effect on cell viability. Chemical characterisation of both extracts allowed us to identify flavonoids and bicyclic sesquiterpenes as the major compounds by HPLC-PAD- HRMS/MS and by molecular network approaches. Bio-guided isolation of bioactive compounds is ongoing in order to identify the responsible compounds of the anti-inflammatory activity of extracts.

 

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Artikel online veröffentlicht:
16. November 2023