Effects of Iso-mukaadial acetate on glucose homeostasis, insulin secretion and haematological function in streptozotocin-induced diabetic rats

Diabetes is a chronic, progressive metabolic disorder which is becoming a global health risk, as its prevalence is increasing steadily worldwide. Warburgia salutaris (Bertol. f.) Chiov. [Canellaceae] is traditionally used to treat diabetes. The use of hypoglycaemic plants to manage this condition is a common practice in developing countries. In the present study, iso-mukaadial acetate (MA) from the ground stem bark of W. salutaris was evaluated for its effect on blood glucose, insulin level and haematological parameters in a streptozotocin (STZ) induced diabetic rat model. Male Sprague-Dawley rats were randomly divided into untreated and treated groups with MA (0.5, 1.5 and 2.5 mg/kg), acarbose (10 mg/kg) and crude extract (1.5 mg/kg). Diabetes was induced in the diabetic group and treatment was administered for five days (Days 8-12). Treatment with MA improved body weight, white blood cells, haemoglobin and eosinophil levels with a moderate decrease in neutrophils in comparison to the diabetic control animals. MA at its lowest dose (0.5 mg/kg) improved red blood cell production and significantly increased lymphocytes, with a marginal decrease in monocytes in comparison to the diabetic control animals. It was further observed that MA at its lowest dose decreased blood glucose concentration and slightly increased insulin level, compared to the highest doses of MA. The data of this study suggests that administration of iso-mukaadial acetate at its lowest concentration modulates diabetes-induced haematological changes. However, further experimental studies are required to substantiate its relevant therapeutic effects.

 

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Publication History

Article published online:
16 November 2023