Effects of selected flavonoids isolated from Cirsium palustre on colon motility – an ex vivo study

Cirsium palustre (L.) Scop. (Asteraceae) is a species commonly found in Europe, Siberia, northern USA and Canada. Previous studies have proven the effect of extracts and fractions obtained from this plant on intestinal motility. The study presented herein was aimed to verify the usefulness of flavonoids apigenin (AP), luteolin (LUT), apigenin 7-O-glucuronide (APG), and chrysoeriol (CHRY) isolated from C. palustre to modify colon motility [1]. The experiment was performed on a porcine intestine model for future use in translational medicine. Colon specimens were incubated in modified Krebs-Henseleit solution under isometric conditions [2]. The effect of all analysed flavonoids on the spontaneous and acetylcholine (ACh)- provoked contractility of colon was verified. The results indicated that all the examined flavonoids are potent modifiers of colon motility. The spontaneous and ACh-induced activity was significantly enhanced in the presence of AP and APG. Contrariwise, LUT and CHRY caused spasmolytic effect in case of both spontaneous and ACh-evoked activity. Considering the complex pathophysiology of disorder of gut-brain interaction and the lack of fully satisfactory treatment methods, flavonoids when properly selected, seem to be an interesting solution in symptomatic treatment.

 

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• References

• 1 Nazaruk J.. Flavonoid compounds from Cirsium palustre (L.) Scop. flower heads. Biochem Syst Ecol 2009; 37: 525
• 2 Mendel M., Chłopecka M., Latek U., Karlik W., Tomczykowa M., Strawa J., Tomczyk M.. Evaluation of the effects of Bidens tripartita extracts and their main constituents on intestinal motility – an ex vivo study. J Ethnopharmacol 2020; 259: 112982

Publikationsverlauf

Artikel online veröffentlicht:
16. November 2023