Planta Med 2023; 89(14): 1395-1396
DOI: 10.1055/s-0043-1774181
Abstracts
Wednesday 5th July 2023 | Poster Session III
Phytochemistry III – Ethnopharmacology; Ethnobotany II; Quality; Monographs; Safety; Stability

Asphodelus bento-rainhae and Asphodelus macrocarpus root extracts pre- clinical safety assessments

Maryam Malmir
1   Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003, Lisbon, Portugal
,
Katelene Lima
1   Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003, Lisbon, Portugal
,
Sérgio Póvoas Camões
1   Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003, Lisbon, Portugal
,
Paula Duarte
2   MEtRICs/Chemistry Department, Nova School of Science and Technology, Universidade Nova de Lisboa, 2829- 516, Caparica, Portugal
,
Joana Paiva Miranda
1   Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003, Lisbon, Portugal
,
Manuela Caniça
3   National Reference Laboratory of Antibiotic Resistances and Healthcare-Associated Infections, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, 1649-016, Lisbon, Portugal
4   Centre for the Studies of Animal Science, Institute of Agrarian and Agri-Food Sciences and Technologies, University of Porto, Porto, Portugal
5   AL4AnimalS, Associate Laboratory for Animal and Veterinary Sciences, Portugal
6   CIISA, Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Portugal
,
Beatriz Silva Lima
1   Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003, Lisbon, Portugal
,
Olga Silva
1   Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003, Lisbon, Portugal
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    Herbal medicines generally have minimal safety concerns compared to synthetic medicines; however, they are not free from toxicity or side effects. Due to the significant increase in global consumption, the safety of herbal medicines has been highlighted. Asphodelus bento-rainhae subsp. bento-rainhae and Asphodelus macrocarpus subsp. macrocarpus root tubers have been traditionally used in Portugal to treat inflammatory and infectious skin diseases. Given the lack of scientific evidence on the safety and efficacy of both Asphodelus medicinal plants, the present study aims to evaluate the toxicity of their hydroethanolic (70% and 96%) root extracts. Cytotoxicity was assessed by MTT assay using HepG2 and HaCaT cells and genotoxicity by bacterial reverse mutation assay (Ames test) with and without metabolic activation according to OECD guidelines. The obtained results showed no cytotoxic (up to 125 μg/mL) or genotoxic/mutagenic potential (up to 5000 μg/plate, with/without metabolic activation) for the two extracts of both species. Although further studies are needed to complete the safety profile of these two medicinal plants, the obtained negative results provide relevant contributions to their toxicological profiles and important contributions to their future use as therapeutic resources.


     

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    Artikel online veröffentlicht:
    16. November 2023

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