Anti-proliferative activity of β-damascenone and related C13- norisoprenoids

Damascenone and ionones are structurally related C13-norisoprenoids. Recent studies focused on the promising anti-proliferative activity of β-ionone and its analogs [1], but did not consider β-damascenone.

We could recently demonstrate that β-damascenone inhibits cell growth in various cancer cell lines, including human leukemia, melanoma and glioblastoma cells. In all cell lines, β-damascenone was more active than β-ionone, which showed only weak inhibition rates at concentrations below 100 µM. Our experiments also showed that the toxicity of β-damascenone towards non-malignant cell lines was reduced compared to cancer cell lines, indicating a selective mechanism. Furthermore, the results indicated a link to caspase 3/7 induced apoptosis [2].

Also, the effect of various damascenone and ionone analogs on cancer cell lines was investigated. Among the tested compounds, β-damascenone was still the most effective, with IC₅₀ values between 8 and 30 µM.

 

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• References

• 1 Ansari M, Emami S.. β-Ionone and its analogs as promising anticancer agents. Eur J Med Chem 2016; 123: 141-154
• 2 Pirker T, Bauer R.. Comparison of anti-proliferative activity of β-damascenone and β-ionone. Planta Medica 2022; 88 (15) 1428

Publikationsverlauf

Artikel online veröffentlicht:
16. November 2023