Effects of Tri-Kesornmas, a Thai traditional herbal formular, on improvement of memory deficit induced by scopolamine in mice

Tri-Kesornmas formular (TKM) has been used as a traditional Thai medicine for a long time. It is composed of 3 herbal plants including Jatropha multifida, Nelumbo nucifera and Aegle marmelos which show diverse biological activities related to Alzheimer’s disease (AD). Based on the activities of its components, TKM might have potential for AD treatment. Thus, the present study aimed to investigate the effects of TKM formula on biological activities related pathology of AD and on the improvement of cognitive impairment induced by scopolamine in mice. Our in vitro results showed that the ethanol extracts of TKM possessed antioxidant, anti-butyrylcholinesterase, anti-beta-amyloid aggregation and neuroprotective activities. For the Morris water maze test which reflects in long-term memory, pretreatment of mice with TKM at the concentration of 250 and 500 mg/kg/day for 14 days significantly decreased escape latency time when compared with the only scopolamine treated mice. In addition, it significantly increased% alternation measured by the Y-maze test which was used as a measure of short-term memory. The in vivo results indicated that TKM could improve both short-term and long-term memory. Conclusively, TKM possesses multimode of action involved with AD pathology cascade and shows an ability to improve both short-term and long-term memory deficit induced by scopolamine.

 

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Publication History

Article published online:
16 November 2023