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DOI: 10.1055/s-0043-1775446
Design and Synthesis of a Novel 1,2,4-Oxadiazole Derivative: 3-(3-(5-((4-Phenylpiperazin-1-yl)methyl)-1,2,4-oxadiazol-3-yl) phenoxy)propan-2-olamines
Abstract
The synthesis of novel heterocyclic 3-(3-(5-((4-phenylpiperazin-1-yl)methyl)-1,2,4-oxadiazol-3-yl)phenoxy)propan-2-olamine derivatives, in particular piperazine and piperidine derivatives of 1,2,4-oxadiazole, is reported. These compounds are a distinguished motif for biological studies. An effective piperazine and piperidine derivative methodology on 1,2,4-oxadiazole substrates has been developed. This pathway, along with good yields and clean reactions, has a broad substrate scope and provides new biologically useful moieties that can be further investigated for their applicability.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1775446.
Included are copies of 1H NMR and HRMS spectra of compounds 9.
- Supporting Information
Publikationsverlauf
Eingereicht: 24. November 2024
Angenommen nach Revision: 19. Januar 2025
Artikel online veröffentlicht:
01. April 2025
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