Abstract
A visible-light-driven, molecular dye-catalyzed C-3 methylation strategy for quinoxalin-2(1H)-ones has been successfully developed. The methodology demonstrates broad substrate
compatibility with various substituted quinoxalin-2(1H)-ones, which could react with N,N,N′,N′,N′′-pentamethyldiethylenetriamine (PMDETA) efficiently at room temperature under ambient
atmospheric conditions to afford the corresponding 3-methylquinoxalinone derivatives
in moderate to good yields. It is noteworthy that this protocol offers a simple, clean,
and transition-metal-free approach, establishing a practical and eco-friendly methodology
for constructing diverse C3-methylated quinoxalinone scaffolds, complementing existing
synthetic strategies for site-selective functionalization of these heterocycles.
Key words
photocatalysis - methylation - quinoxalin-2(1
H)-ones - dye molecules - photosensitizers
