Planta Med 2000; 66(4): 364-365
DOI: 10.1055/s-2000-8554
Letter
Georg Thieme Verlag Stuttgart · New York

Agelasine F from a Philippine Agelas sp. Sponge Exhibits in vitro Antituberculosis Activity

Gina C. Mangalindan1 , Meliza T. Talaue1 , Lourdes J. Cruz1 , Scott G. Franzblau2 , Linda B. Adams2 , Adam D. Richardson3 , Chris M. Ireland3 , Gisela P. Concepcion1,*
  • 1 Marine Science Institute, University of the Philippines, Quezon City, Philippines
  • 2 Laboratory Research Branch, National Hansen's Disease Center, Louisiana State University, Baton Rouge, LA, U.S.A.
  • 3 Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, U.S.A.
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

Marine sponge samples were collected in Baler, Aurora, Philippines, and extracts were tested for in vitro antituberculosis activity. An orange Agelas sp. sponge yielded the known compound, agelasine F, which inhibited some drug resistant strains of Mycobacterium tuberculosis in vitro at concentrations as low as 3.13 μg/ml. Activity against M. tuberculosis residing within macrophages required concentrations of 13 - 22 μg/ml which was below the IC50 for Vero cells (34 μg/ml).

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Gisela P. Concepcion

Marine Science Institute University of the Philippines

Diliman Quezon City 1101

Philippines

Email: giselapc@compass.com.ph

Phone: +632-921-3799

Fax: +632-433-2990

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