Abstract
The isolation and characterisation of (S )-(+)-6-methoxy-α-methyl-2-naphthaleneacetic acid, a well known synthetic non-steroidal
anti-inflammatory drug (naproxene), from a natural source is described for the first
time. We evaluated the ability of naproxene and its 7-methoxy isomer to abrogate constitutive
COX-1 and inducible COX-2 activity in human A549 cells. Naproxene inhibited COX-1
(IC50 = 3.42 μM) and COX-2 (IC50 = 1.53 μM), whereas the 7-methoxy isomer had no appreciable effect on COX-1 (IC50 >> 100 μM) but also abrogated the activity of COX-2 enzyme (IC50 = 14.42 μM).
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Prof. Dr. Javier G. Luis
Instituto Universitario de Bio-Orgánica Universidad de La Laguna
Avda. Francisco Sánchez, 2
38206 La Laguna
Tenerife
Spain
Email: jgutluis@ull.es
Phone: 922-318571
Fax: 922-318574