Planta Med 2000; 66(5): 439-443
DOI: 10.1055/s-2000-8582
Original Paper
Georg Thieme Verlag Stuttgart · New York

Effect of Honey on Naringin Absorption from a Decoction of the Pericarps of Citrus grandis

Yu-Chi Hou1 , Su-Lan Hsiu2 , Hsiu-Fang Yen2 , Chung-Chuan Chen1 , Pei-Dawn Lee Chao2,*
  • 1 Graduate Institute of Chinese Pharmaceutical Sciences, Taichung, Taiwan, R.O.C.
  • 2 Department of Pharmacy, China Medical College, Taichung, Taiwan, R.O.C.
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

To measure naringin/naringenin absorption of a decoction prepared from the pericarps of Citrus grandis and to investigate the effect of honey on naringin/naringenin absorption, six healthy males received 200 mL decoctions of untreated and honey-treated Pericarpium Citri Grandis in a randomized crossover design. The absorption was measured by renal recovery of naringenin glucuronides/sulfates over 48 hours. The contents of naringin/naringenin in 200 mL decoctions of untreated and honey-treated Pericarpium Citri Grandis were determined to be 261.5/23.8 μmol and 303.3/11.6 μmol, respectively. The mean cumulated renal excretion of naringenin glucuronides/sulfates after intake of these two decoctions were 74.8 μmol (26.2 % of dose) and 49.8 μmol (15.8 % of dose), respectively. Paired Student’s t-test showed that the difference of the total renal recovery of naringin/naringenin between the two decoctions was significant. The results indicated that honey significantly reduced naringin/naringenin absorption by 33.4 % in humans and suggested that honey treatment might alter the efficacy of Pericarpium Citri Grandis.

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Prof. Pei-Dawn Lee Chao

Department of Pharmacy China Medical College

Taichung

Taiwan 404

R. O. C.

Email: pdlee@mail.cmc.edu.tw

Phone: 886-4-2033108

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