Planta Med 2001; 67(2): 153-155
DOI: 10.1055/s-2001-11511
Original Paper

© Georg Thieme Verlag Stuttgart · New York

A New Diterpenoid with Antispasmodic Activity from Salvia cinnabarina

Giovanni Romussi1,*, Giovanni Ciarallo1 , Angela Bisio2 , Nadia Fontana1 , Francesco De Simone3 , Nunziatina De Tommasi3 , Nicola Mascolo4 , Luisa Pinto4
  • 1 Dipartimento di Chimica e Tecnologie Farmaceutiche e Alimentari, Università di Genova, Genova, Italy
  • 2 Istituto Botanico Hanbury, Università di Genova, Genova, Italy
  • 3 Dipartimento di Scienze Farmaceutiche, Università di Salerno, Salerno, Italy
  • 4 Dipartimento di Farmacologia Sperimentale, Univesità di Napoli, Napoli, Italy
Further Information

Publication History

March 23, 2000

July 16, 2000

Publication Date:
31 December 2001 (online)

Abstract

From the leaf surface exudate of the aerial parts of Salvia cinnabarina a new secoisopimarane diterpenoid with a non-specific spasmolytic activity on histamine-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum was obtained. The IC50 value obtained was comparable with that obtained for papaverine. The structure of 3,4-secoisopimara-4(18),7,15-triene-3-oic acid was established by 1D and 2D NMR spectroscopic techniques.

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Prof. G. Romussi

Dipartimento di Chimica e Tecnologie Farmaceutiche ed Alimentari

Università di Genova

Via Brigata Salerno

16147 Genova

Italy

Email: romussi@dictfa.unige.it