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DOI: 10.1055/s-2001-11511
© Georg Thieme Verlag Stuttgart · New York
A New Diterpenoid with Antispasmodic Activity from Salvia cinnabarina
Publication History
March 23, 2000
July 16, 2000
Publication Date:
31 December 2001 (online)
Abstract
From the leaf surface exudate of the aerial parts of Salvia cinnabarina a new secoisopimarane diterpenoid with a non-specific spasmolytic activity on histamine-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum was obtained. The IC50 value obtained was comparable with that obtained for papaverine. The structure of 3,4-secoisopimara-4(18),7,15-triene-3-oic acid was established by 1D and 2D NMR spectroscopic techniques.
Key words
Salvia cinnabarina - Lamiaceae - secoisopimarane-diterpene - antispasmodic acitivity
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Prof. G. Romussi
Dipartimento di Chimica e Tecnologie Farmaceutiche ed Alimentari
Università di Genova
Via Brigata Salerno
16147 Genova
Italy
Email: romussi@dictfa.unige.it