Inhibitory Effects of Maesanin and Analogs on Arachidonic Acid Metabolizing Enzymes

Ehab A. Abourashed; Ilias Muhammad; Marion Resch; Rudolf Bauer; Farouk S. El-Feraly; Charles D. Hufford

doi:10.1055/s-2001-14316

Planta Med 2001; 67(4): 360-361
DOI: 10.1055/s-2001-14316

Letter

Inhibitory Effects of Maesanin and Analogs on Arachidonic Acid Metabolizing Enzymes

Ehab A. Abourashed¹ , Ilias Muhammad¹ , Marion Resch³ , Rudolf Bauer³ , Farouk S. El-Feraly⁴ , Charles D. Hufford^{1, 2,}*

¹ National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, Mississippi, U.S.A.
² Department of Pharmacognosy School of Pharmacy, University of Mississippi, University, Mississippi, U.S.A.
³ Institute of Pharmaceutical Biology, University Düsseldorf, Düsseldorf, Germany
⁴ Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Abstract

The substituted 1,4-benzoquinone, maesanin (1), is a potent 5-lipoxygenase (5-LO) inhibitor present in the fruit of Maesa lanceolata Forssk. Thirteen natural, synthetic, semisynthetic, and microbially transformed analogs of 1 were tested for their in vitro inhibition of 5-lipoxygenase (5-LO) and cyclooxygenase-1 (COX-1). Maesanin was the most active 5-LO inhibitor. All other analogs were inactive or less active than the natural products as 5-LO inhibitors. None of the tested compounds was strongly active in the COX-1 inhibition assay.

Full Text

References

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Dr. Charles D. Hufford

University of Mississippi,

School of Pharmacy,

University

MS 38677

U.S.A.

Email: chufford@olemiss.edu

Fax: (662)915-5704