Synthesis of (S)-N-Boc-3-Amino-2-Arylpropanol from Optically Active β-Amino Esters

Monique Calmès; Françoise Escale; Jean Martinez

doi:10.1055/s-2001-15237

SHORTPAPER

Synthesis of (S)-N-Boc-3-Amino-2-Arylpropanol from Optically Active β-Amino Esters

Monique Calmès*, Françoise Escale, Jean Martinez
Laboratoire des Aminoacides, Peptides et Protéines, UMR-CNRS 5810, Universités Montpellier I et II, Place E. Bataillon, 34095 Montpellier cedex 5, France
Fax: +33(4)67144866; e-Mail: monique@univ-montp2.fr;

Abstract

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Abstract

The reduction of various (αS,3"R)-pantolactonyl-2-aryl-3-phthalimidopropanoates 3 followed by an acidic treatment and direct N-Boc protection afforded the corresponding (S)-N-Boc-3-amino-2-arylpropanols 4 in good yield and without loss of the optical purity.

Keys words

1,3-amino alcohols - reduction - β-amino esters

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References

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