A Simple Route to N-ω-Chloroalkylisatins from Cyclic t-Anilines, Oxalyl Chloride and DABCO

Abstract

para-Substituted N-phenylpyrrolidines, -piperidines, -perhydroazepines and -morpholines react with oxalyl chloride and DABCO to give the pharmaceutically useful intermediates, N-ω-haloalkylisatins, under mild conditions and generally good yields.

cyclic t-anilines - oxalyl chloride - DABCO - N-ω-haloalkylisatins

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