A Convenient Synthesis of Perfluoroalkylated Indolizinylphosphonates

Abstract

A convenient method for the synthesis of perfluoroalkylated indolizinyl-phosphonates via the 1,3-cycloaddition of pyridinium N-ylide and perfluoroalkynyl phosphonate in 49-77% yields is described.

Key words

perfluoroalkylated indolizinylphosphonate - 1,3-cycloaddition - pyridinium N-ylide - perfluoroalkynylphosphonate

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  1-Phenacylpyridinium bromide and 1-(Cyanomethyl)pyridinium chloride were obtained from Aldrich Company.