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Synthesis 2002(7): 0901-0905
DOI: 10.1055/s-2002-28512
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of New Fluorine Containing Triazolo- and Tetrazolopyrimidines

Arcady L. Krasovsky, Andrew M. Moiseev, Valentine G. Nenajdenko*, Elizabeth S. Balenkova
Department of Chemistry, Moscow State University, 119899 Moscow, Russia
Fax: +7(095)9328846; e-Mail: Nen@acylium.chem.msu.su;
Further Information

Publication History

Received 5 February 2002
Publication Date:
14 May 2002 (online)

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Abstract

The reaction of 1,1,1-trifluoro-4-(sulfonyl)-but-3-ene-2,2-dioles 1a,b with corresponding aminoazoles was investigated. A new simple and efficient way for the regioselective synthesis of 5-CF3 or 7-CF3 triazolo- and tetrazolopyrimidines is described.

Key words

cycloaddition - heterocycles - triazolopyrimidine - tetrazolopyrimidine - sulfones

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Krasovsky, A. L.; Nenajdenko, V. G.; Balenkova, E. S. Synthesis 2002, in press.

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Krasovsky, A. L.; Moiseev A. M.; Nenajdenko, V. G.; Balenkova, E. S. Khim. Het. Soedin 2002, in press.