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Synthesis 2002(8): 1096-1100
DOI: 10.1055/s-2002-31963
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© Georg Thieme Verlag Stuttgart · New York

Synthesis of New Thieno[b]azepinediones from α-Methylene Ketones

Evelyne Migianu, Gilbert Kirsch*
Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Faculté des Sciences, Université de Metz, Ile du Saulcy, 57045 Metz Cedex, France
Fax: +33(3)87315333; e-Mail: kirsch@sciences.univ-metz.fr;
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Publication History

Received 25 January 2002
Publication Date:
03 June 2002 (online)

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Abstract

New substituted 6,7-dihydro-4H-thieno[3,2-b]azepine-5,8-diones were synthesized in seven steps, starting from substituted α-methylene ketones, via 3-aminothiophene-2-carboxylic acid alkyl esters.

Key words

heterocycles - thieno[b]azepinediones - α-methylene ketones - 3-aminothiophene-2-carboxylic acid alkyl esters