Indoles as Nucleophiles in a Self-Catalytic Michael Reaction

Abstract

C-3 Substituted indoles 7a-c were regioselectively synthesized in high yields by reacting indole 2 and electron-rich indoles 3,4 with acrylate 1. Additions of electron-deficient indoles 5,6 to the acrylate 1 gave N-substituted indoles 9a,b.

Key words

indoles - Michael reaction - regioselectivity - phosphonic acids

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