Synthesis of Chiral n,n+1-Diamino Acids and their Application to the Construction of Dendrimers

Abstract

Efficient methods for the synthesis of chiral n,n+1-diamino acids starting from l-glutamic acid were developed. A second generation prototype amino acid based dendrimer, containing 1,3-propanediamine as the core and 4,5-diaminopentanoic acid as the branching unit, was synthesised following the divergent approach. Diaminobutane poly(propyleneimine) dendrimers modified at the periphery with n,n+1-diamino acids were synthesized and characterized.

Key words

amides - amino acids - azides - coupling - dendrimers

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