Tetrabutylammonium Peroxydisulfate in Organic Synthesis; XIII. A Simple and Highly Efficient One-Pot Synthesis of Nitriles by Nickel-Catalyzed Oxidation of Primary Alcohols with Tetrabutylammonium Peroxydisulfate

Fen-Er  Chen; Yong-Ye  Li; Mei  Xu; Hui-Qing  Jia

doi:10.1055/s-2002-33906

SHORTPAPER

Tetrabutylammonium Peroxydisulfate in Organic Synthesis; XIII. [1] A Simple and Highly Efficient One-Pot Synthesis of Nitriles by Nickel-Catalyzed Oxidation of Primary Alcohols with Tetrabutylammonium Peroxydisulfate

Fen-Er Chen*, Yong-Ye Li, Mei Xu, Hui-Qing Jia
Department of Chemistry, Fudan University, Shanghai 200433, P. R. China
Fax: +86(21)65642021; e-Mail: rfchen@fudan.edu.cn;

Abstract

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Abstract

A facile one-pot method is presented for the synthesis of nitriles from the corresponding primary alcohols by nickel-catalyzed oxidation with tetrabutylammonium peroxydisulfate in the presence of ammonium hydrogen carbonate under basic aqueous conditions. This convenient synthetic method provides an easy and simple access to various aliphatic, aromatic and heterocyclic nitriles in excellent yields with very high purity.

Key words

tetrabutylammonium peroxydisulfate - nitriles - primary alcohols - oxidation

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References

Part XII: Chen, F. E.; Lu Y. W.; He, Y. P.; Luo, Y. F.; Yan, M. G. Synth. Commun. 2002, in press.

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