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Synthesis 2002(16): 2416-2420
DOI: 10.1055/s-2002-35238
PAPER
© Georg Thieme Verlag Stuttgart · New York

Isocyanatophosphoric Acid Dichloride: A Novel Reagent for the Introduction of a Cyano Group into the Molecules of Electron-Rich Heterocycles and Enamines­

Radomir V. Smaliy*a, Aleksandra A. Chaikovskayaa, Aleksandr M. Pinchuka, Andrei A. Tolmachevb
a Institute of Organic Chemistry, National Academy of Sciences of the Ukraine, Murmanska Str. 5, Kyiv-94, 02094, Ukraine
Fax: +38(44)5732643; e-Mail: iochkiev@ukrpack.net;
b Kyiv National Taras Shevchenko University, Volodymyrska Str. 64, Ukraine
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Publication History

Received 7 June 2002
Publication Date:
04 November 2002 (online)

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Abstract

A new synthetic method is developed which enables a direct one-step introduction of a cyano group into electron-rich heterocyclic systems of the indole, pyrrole, and indolizine series, and also to enamines using isocyanatophosphoryl dichloride.

Key words

nitriles - isocyanatophosphoryl dichloride - indoles - pyrroles - indolizines - enamines