One-Pot and Stereospecific Synthesis of cis-1,2-Diazides via Mitsunobu Reaction­ of Epoxides

Abstract

Mitsunobu reaction of epoxides using hydrazoic acid, diethylazodicarboxylate, and triphenylphosphine as reagents gave the corresponding cis-1,2-diazides in moderate yield. Application of similar reaction conditions to trans-diols furnished the corresponding trans-1,2-diazides.

Mitsunobu reaction - cis-1,2-diazides - trans-1,2-di­azides - epoxides - trans-1,2-diols

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