Pughiinin A, a Sesquiterpene from the Fungus Kionochaeta pughii BCC 3878

Abstract

A novel secondary metabolite, pughiinin A, together with pycnidione, mevalonolactone, and 7-hydroxy-2-methylchromanone, was isolated from the seed fungus Kionochaeta pughii BCC 3878. The chemical structure was established by spectroscopic methods and by single crystal X-ray crystallography. Pughiinin A and pycnidione exhibited in vitro antiplasmodial activity against Plasmodium falciparum (K1 strain). Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC₅₀ values of 2.0 and 1.6 μg/mL, respectively.

Key words

Seed fungus - antiplasmodial activity - anti-cancer activity - Kionochaeta pughii

References

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