Planta Med 2002; 68(11): 995-998
DOI: 10.1055/s-2002-35657
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Polyphenols from the Heartwood of Cercidiphyllum japonicum and their Effects on Proliferation of Mouse Hair Epithelial Cells

Keisuke Towatari1 , Kiyo Yoshida1 , Nobuhiro Mori1 , Kuniyoshi Shimizu1 , Ryuichiro Kondo1 , Kokki Sakai1
  • 1Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
Further Information

Publication History

Received: February 8, 2002

Accepted: June 1, 2002

Publication Date:
26 November 2002 (online)

Abstract

The methanol extract of heartwood of Cercidiphyllum japonicum (Cercidiphyllaceae) stimulated proliferation of mouse hair epithelial cells, similar to minoxidil and procyanidin B-2. (+)-Taxifolin (2), quercetin (3), myricetin (4), (+)-dihydromyricetin (5) and gallic acid (6) were isolated from C. japonicum and showed significant proliferative activities on the hair epithelial cells.

References

  • 1 Katz H I. Topical minoxidil: review of efficacy and safety.  Cutis. 1989;  43 94-8
  • 2 Tanigaki-Obana N, Ito M. Effects of cepharanthine and minoxidil on proliferation, differentiation and keratinization of cultured cells from the murine hair apparatus.  Archives of Dermatological Research. 1992;  284 290-6
  • 3 Takahashi T, Kamiya T, Hasegawa A, Yokoo Y. Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo .  The Journal of Investigative Dermatology. 1999;  112 310-6
  • 4 Takahashi T, Kamimura A, Yokoo Y, Honda S, Watanabe Y. The first clinical trial of topical application of procyanidin B-2 to investigate its potential as a hair growing agent.  Phytotherapy Research. 2001;  15 331-6
  • 5 Tanigaki N, Ando H, Ito M, Hashimoto A, Kitano Y. Electron microscopic study of cultured cells from the murine hair tissues: cell growth and differentiation.  Archives of Dermatological Research. 1990;  282 402-7
  • 6 Nakaoji K, Nayeshiro H, Takahashi T. Norreticuline and reticuline as possible new agents for hair growth acceleration.  Biological & Pharmaceutical Bulletin. 1997;  20 586-8
  • 7 Shirai A, Ikeda J, Kawashima S, Tamaoki T, Kamiya T. KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models.  Journal of Dermatological Science. 2001;  25 213-8
  • 8 Janes N F, Morgan J WW. The occurrence of dihydrokampferol in Nothofagus species.  Journal of the Chemical Society. 1960;  2560-5
  • 9 Kondo T. On the chemical constituents of the heartwood of Distylium racemosum S. et Z.  Journal of the Faculty of Agriculture, Kyushu University. 1951;  10 79-99
  • 10 Imamura H, Kurosu H, Takahashi T. The chemistry of wood extractives. XVIII. The heartwood constituents of Rhus javanica L.  Mokuzai Gakkaishi. 1967;  13 295-9
  • 11 Mabry T J, Markham K R, Thomas M B. In The systematic identification of flavonoids. Springer-Verlag New York Inc 1970: 309
  • 12 Miller J M, Bohm B A. Flavonoids of Laptarrhena pyrolifolia. .  Phytochemistry. 1979;  18 1412-3
  • 13 Schultz T P, Harms W B, Fisher T H, Mcmurtrey K D, Minn J, Nicholas D D. Durability of angiosperm heartwood-The importance of extractives.  Holzforschung. 1995;  49 29-34
  • 14 Schwartz P M, Kugelman L C, Coifman Y, Hough L M, Milstone L M. Human keratinocytes catabolize thymidine.  The Journal of Investigative Dermatology. 1988;  90 8-12
  • 15 Schwartz P M, Milstone L M. Dipyridamole potentiates the growth-inhibitory action of methotrexate and 5-fluorouracil in human keratinocytes in vitro .  The Journal of Investigative Dermatology. 1989;  93 523-7
  • 16 vanAcker S ABE, vandenBerg D J, Tromp M NJL, Griffioen D H, vanBennekom W P, vanderVijgh W JF, Bast A. Structural aspects of antioxidant activity of flavonoids.  Free Radical Biology and Medicine. 1996;  20 331-42
  • 17 Okuda T. Novel aspects of tannins-renewed concepts and structure-activity relationships.  Current Organic Chemistry. 1999;  3 609-22

Prof. Ryuichiro Kondo

Laboratory of Systematic Forest and Forest Products Science

Department of Forestry and Forest Products Sciences

Faculty of Agriculture

Kyushu University

6-10-1 Hakozaki

Higashi-ku

Fukuoka, 812-8581

Japan

Phone: /Fax: +81-92-642-2811

Email: kondo@brs.kyushu-u.ac.jp