An Easy Access to (E)-Alkylidenesuccinic Acids [1]

Abstract

A two-step simple, efficient and general approach to (E)-alkylidenesuccinic acids 1a-e has been demonstrated in 82-88% overall yields via condensation of Wittig adduct of maleimide 2 and triphenylphosphine with aliphatic aldehydes followed by acid-catalyzed hydrolysis pathway.

Key words

maleimide-triphenylphosphine adduct - aliphatic aldehydes - condensations - hydrolysis - alkylidenesuccinic acids

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NCL Communication No. 6632.

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NCL Communication No. 6632.