Highly Substituted Isoxazoles: The Baylis-Hillman Reaction of Substituted 4-Isoxazolecarbaldehydes and Attempted Cyclization to Isoxazole-Annulated Derivatives [1]

Abstract

In an attempt to understand the effect of position of the formyl group on the efficiency of Baylis-Hillman reaction within isoxazolecarbaldehydes, the reactions of substituted 4-isoxazolecarbaldehydes to obtain highly substituted isoxazoles are described. Attempts to obtain isoxazole-annulated derivatives from these Baylis-Hillman adducts involving S_NR′-S_NAr substitution strategy are also described.

Baylis-Hillman reaction - 4-isoxazolecarbaldehyde - DABCO - DMAP

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