Convenient One-Pot Synthesis of 4-(Dialkylaminobenzyl)triphenylphosphonium Salts - Application to the Synthesis of a Fluorescent Probe for Multiphotonic Imaging of Biological Membranes

Abstract

An efficient one-pot preparation of (dialkylaminobenzyl)triphenylphosphonium salts directly from dialkylbenzenamine is described. The one-pot procedure proceeds quickly in high yields and allows the synthesis of useful reagents for Wittig reaction. Their potential is illustrated by the synthesis of a bolaamphiphilic fluorophore of interest for biological membrane imaging.

Key words

phosphorus - amines - Wittig reactions - alkenation - fluorescence­ - conjugation

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