Organic Reactions in Ionic Liquids;Ionic Liquid-Accelerated Three-Component Reaction: A Rapid One-PotSynthesis of 3-Alkyl-5-[(Z)-arylmethylidene]-1,3-thiazolidine-2,4-diones

De-Hong Yang; Zhen-Chu Chen; Song-Ying Chen; Qin-Guo Zheng

doi:10.1055/s-2003-40980

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Synthesis 2003(12): 1891-1894
DOI: 10.1055/s-2003-40980

PAPER

Organic Reactions in Ionic Liquids;Ionic Liquid-Accelerated Three-Component Reaction: A Rapid One-PotSynthesis of 3-Alkyl-5-[(Z)-arylmethylidene]-1,3-thiazolidine-2,4-diones

De-Hong Yang^b, Zhen-Chu Chen*^a,b, Song-Ying Chen^b, Qin-Guo Zheng^c
^a Ningbo Institute of Technology, Zhejiang University, Ningbo, 315104, P.R. China
e-Mail: zhenchuc@mail.hz.zj.cn;
^b Department of Chemistry, Zhejiang University (XiXi Campus), HangZhou,310028, P. R. China
^c Pharmaceutical Sciences Research Institute, Aston University, Aston Triangle, BirminghamB4 7ET, UK

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Publication History

Received 9 April 2003
Publication Date:
30 July 2003 (online)

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Abstract

A rapid one-pot synthesis of 3-alkyl-5-[(Z)-arylmethylidene]-1,3-thiazolidine-2,4-dionesis described that occurs in recyclable ionic liquid [bmim]PF₆ (1-butyl-3-methylimidazolium hexafluorophosphate).Significant rate enhancement and good selectivity have been observed.

Key words

three-component reaction - 1,3-thiazolidine-2,4-diones - ionic liquid

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