Synthesis 2003(18): 2768-2770  
DOI: 10.1055/s-2003-42461
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

A New and Facile Iodine(III)-Mediated Approach for the Regioselective Alkoxylation of 2,5-Dihydroxyacetophenone

Om Prakash*, Rashmi Pundeer, Harpreet Kaur
Chemistry Department, Kurukshetra University, Kurukshetra, Haryana 136119, India
Fax: +91(1744)238277; e-Mail: oprakash50@sify.com;
Further Information

Publication History

Received 21 July 2003
Publication Date:
05 November 2003 (online)

Abstract

Oxidation of 2,5-dihydroxyacetophenone with iodobenzene diacetate (IBD) in different alcohols leads to regioselective alkoxylation, thereby providing a new and convenient route for the synthesis of 6-alkoxy-2,5-dihydroxyacetophenones.

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There was no significant increase in the yields by running the reaction for longer time or by adding more IBD.