Planta Med 2004; 70(2): 160-165
DOI: 10.1055/s-2004-815494
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Four New Stilbenoids from the Lianas of Gnetum montanum f. megalocarpum

Xiao-mei Li1 , Mao Lin1 , Ying-hong Wang1 , Xin Liu1
  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China
This research program was supported by the National Natural Science Foundation of China (No. 30,070,889)
Further Information

Publication History

Received: July 14, 2003

Accepted: November 8, 2003

Publication Date:
02 March 2004 (online)

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Abstract

From the lianas of Gnetum montanum Markgr. f. megalocarpum Markgr., four new stilbenoids, gnetumontanins A - D (1 - 4) were obtained together with 16 known compounds. Gnetumontanin A (1) is the first oligostilbene dimerized from two oxyresveratrol units, gnetumontanin B (2) is a new stilbene trimer oligomerized from two oxyresveratrol and one resveratrol units, gnetumontanin C (3) is a new stilbenoid with a novel skeleton having a δ-lactone moiety and gnetumontanin D (4) is a glucoside of 3. Their structures were determined by means of spectroscopic evidence, especially 2D NMR techniques. Gnetumontanin B showed potent inhibition of TNF-α with an inhibitory ratio of 58.1 % (P < 0.05) at a concentration of 10 - 5 mol L-1 and the IC50 was 1.49 × 10 - 6 mol L-1.

References

Prof. Mao Lin

Institute of Materia Medica

Chinese Academy of Medical Sciences and Peking Union Medical College

Beijing 100050

P. R. China

Fax: +86-10-63017757

Email: linmao@imm.ac.cn