Reaction Between Alkyl Isocyanides and Isopropylidene Meldrum’s Acid in the Presence of Pyrrole or Indoles

Abstract

Alkyl isocyanides undergo a smooth reaction with isopropylidene Meldrum’s acid in the presence of pyrrole or indole to produce 1-alkyl-3,3-dimethyl-4-(1H-pyrrole-2-carbonyl)-pyrrolidine-2,5-diones or 1-alkyl-4-(1H-indole-3-carbonyl)-3,3-dimethyl-pyrrolidine-2,5-diones in good yields.

Keywords

pyrrole - indole - alkyl isocyanides - isopropylidene Meldrum’s acid - three-component reaction

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