Simple Preparation of 3-Aryl 2-Piperidinones

Arnault de Filippis; Domingo Gomez Pardo; Janine Cossy

doi:10.1055/s-2004-829193

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Synthesis 2004(17): 2930-2933
DOI: 10.1055/s-2004-829193

PSP

Simple Preparation of 3-Aryl 2-Piperidinones

Arnault de Filippis, Domingo Gomez Pardo, Janine Cossy*
Laboratoire de Chimie Organique associé au CNRS, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), 10 rue Vauquelin, 75231 Paris Cedex 05, France
Fax: +33(1)40794660; e-Mail: janine.cossy@espci.fr;

Further Information

Publication History

Received 20 April 2004
Publication Date:
13 August 2004 (online)

Abstract
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Abstract

A very simple method for obtaining α-arylated N-protected 2-piperidinones in high yields is described. The use of ZnCl₂, LiHMDS or s-BuLi as the base and Pd(dba)₂ as the catalyst are the key factors.

Key words

arylations - lactams - palladium - zinc - coupling

References

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Yield calculated from aryl bromide and the unreacted N-protected 2-piperidinone was recovered.