Phenylpropanoid NF-κB inhibitors from Bupleurum fruticosum

Abstract

Two phenylpropanoids from Bupleurum fruticosum (Apiaceae/Umbelliferae) were shown to inhibit the transcriptional activity induced by PMA or TNFα of an NF-κB-controlled reporter gene. Western blot experiments indicated that the phenylpropanoids did not prevent IκBα degradation, suggesting that their molecular target is at a post-IKB degradation level. Both compounds prevented cytokine (IL-1, IL-6, TNF, IL-8) release and prostaglandin E₂ synthesis.

Abbreviations

AINP:anti-inflammatory natural products (EU-FP5-QLK3-2000-00463)

IκB:inhibitor of NF-κB

IL:interleukin

NF-κB:nuclear factor kappa B

NF-κB - Bupleurum fruticosum - Apiaceae - phenylpropanoids - anti-inflammatory natural products (AINP) - cytokine

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