Three-Component One-Pot Synthesis of Functionalized 1,2,3,6-Tetrahydropyrano[4,3-b]pyrroles

Issa Yavari; Manzarbanoo Esnaashari

doi:10.1055/s-2005-861839

SHORTPAPER

Three-Component One-Pot Synthesis of Functionalized 1,2,3,6-Tetrahydropyrano[4,3-b]pyrroles

Issa Yavari*^a,b, Manzarbanoo Esnaashari^a
^a Department of Chemistry, Science & Research Campus, Islamic Azad University, Ponak, Tehran, Iran
^b Department of Chemistry, Tarbiat Modarres University, PO Box 14115-175, Tehran, Iran
Fax: +98(21)8006544; e-Mail: yavarisa@modares.ac.ir;

Abstract

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Abstract

The reactive 1:1 adduct, produced from the reaction between dialkyl acetylenedicarboxylates and 2,6-dimethylphenyl isocyanide, was trapped by methyl 2,4-dioxopentanoate to yield dialkyl 1-(2,6-dimethylphenyl)-4-methyl-2,3-dioxo-1,2,3,6-tetrahydropyrano[4,3-b]pyrrole-6,7-dicarboxylates in moderate yields.

Key words

three component reaction - Ugi reaction - methyl 2,4-dioxopentanoate - 2,6-dimethylphenyl isocyanide - acetylenic esters

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References

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