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Synthesis 2005(8): 1314-1318  
DOI: 10.1055/s-2005-861860
PAPER
© Georg Thieme Verlag Stuttgart · New York

Regiospecific Synthesis of 1,4,5-Trisubstituted-1,2,3-triazole via One-Pot Reaction Promoted by Copper(I) Salt

Yong-Ming Wu*, Juan Deng, Ya Li, Qing-Yun Chen
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Rd., Shanghai 200032, P. R. China
Fax: +86(21)64166128; e-Mail: ymwu@mail.sioc.ac.cn;
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Publication History

Received 29 November 2004
Publication Date:
09 March 2005 (online)

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Abstracts

A method for the regiospecific synthesis of 1,4,5-trisubstituted-1,2,3-triazole catalyzed by copper(I) iodide was developed. This is the first example of a regiospecific synthesis of 5-iodo-1,4-disubstituted-1,2,3-triazole, which can be further elaborated to a range of 1,4,5-trisubstituted-1,2,3-triazole derivatives.

Key words

fluoroalkyl-1,4,5-trisubstituted-1,2,3-triazole - one-pot reaction - regiospecific synthesis - fluoroalkylazide - terminal alkyne - 1,3-dipolar cycloaddition

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