Cytotoxic Chromenes from Myriactis humilis

Abstract

Two new chromenes, myriachromene and 2,2-dimethyl-6,7-methylenedioxy-2H-chromene, together with ten known compounds including α-tocopherylquinone, α-tocopherol acetate, diphenyl sulfone, β-carotene, chondrillasterol, β-sitosterol, β-sitostenone, vanillin, and vanillic acid were isolated from the whole plant of Myriactis humilis. The structures of these new compounds were determined through spectral analyses. Among the isolates, four compounds exhibited cytotoxicity (ED₅₀ values < 4 μg/mL) against P-388 or HT-29 cell lines in vitro.

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