An Efficient and Practical Procedure for the Synthesis of 4-Substituted Coumarins

Surya K. De; Richard A. Gibbs

doi:10.1055/s-2005-865282

SHORTPAPER

An Efficient and Practical Procedure for the Synthesis of 4-Substituted Coumarins

Surya K. De*, Richard A. Gibbs
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
Fax: +1(765)4941414; e-Mail: skd125@pharmacy.purdue.edu;

Abstract

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Abstract

BiCl₃ is used as an efficient catalyst in the Pechmann condensation reaction of phenols with β-keto esters leading to the formation of coumarin derivatives in excellent yields under solvent-free conditions.

Key words

phenols - β-keto ester - Pechmann reaction - bismuth(III) chloride - coumarin

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References

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